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Montreal Neurological Institute

3801 University St.

Montreal, Quebec, Canada

H3A 2B4

 

McGill

Kennedy Lab


Montreal Neurological Institute

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Doing this, the lab utilizes biochemical and molecular biological approaches, confocal and super-resolution microscopy methods, electrophysiology, primary neuronal cell cultures, mouse transgenesis, and animal models of neural injury and disease.

The Kennedy lab at the Montreal Neurological Institute investigates the molecular mechanisms that regulate cell motility and the formation of specialized cell-cell adhesions in the mammalian central nervous system. These include studies to identify mechanisms regulating axon extension, cell migration and synaptogenesis during development, and myelination, axon regeneration and synaptic plasticity in the mature central nervous system. During development, neurons must often extend an axon great distances to make appropriate connections with their appropriate neuronal targets. We are studying the proteins that direct and regulate neuronal process extension in the embryo. Of particular interest to us, many of the proteins that regulate neural development continue to be produced in the adult nervous system. We are investigating how these contribute to the function of the adult nervous system; in particular, how they may regulate the synaptic connections between nerve cells (synaptic plasticity), promote the maintenance and plasticity of myelin, and influence neuronal regeneration following injury. 

ABOUT US

 
C2C12_DCC_paxilin_nanodot_zoom_averagejpg

C2C12_DCC_paxilin_nanodot_zoom_averagejpg

commissural neuron

commissural neuron

netrin-1 gradient and NFM

netrin-1 gradient and NFM

E11.5 netrin-1-bGal mouse embryo

E11.5 netrin-1-bGal mouse embryo

microcontact printed protein

microcontact printed protein

netrin-1 rat E11 spinal cord

netrin-1 rat E11 spinal cord

oligodendrocyte and astrocyte

oligodendrocyte and astrocyte

commissural growth cone

commissural growth cone

timothy.kennedy@mcgill.ca   |   3801 University Str.      Montreal, Canada

commissural neuron