Publications

Papers

 

1. Castellucci, V.F., Kennedy, T.E., Kandel, E.R., Goelet, P. (1988) A quantitative analysis of 2-D gels identifies proteins in which labeling is increased following long-term sensitization in Aplysia. Neuron 1, 321-328.

 

2. Kennedy, T.E., Gawinowicz,M.A., Barzilai, A., Kandel, E.R., Sweatt, J.D. (1988) Sequencing of proteins from two-dimensional gels by using in situ digestion and transfer of peptides to polyvinylidene difluoride membranes:  Application to proteins associated with sensitization in Aplysia. P.N.A.S. 85, 7008-7012.

 

3. Kennedy, T.E., Wager-Smith, K., Barzilai, A., Kandel, E.R., Sweatt, J.D. (1988) Sequencing proteins from acrylamide gels. Nature 336, 499-500.  

 

4. Palazzolo, M., Katz, F., Kennedy, T.E., Schwartz, J.H. (1989) Multiple cAMP-binding proteins in Aplysia tissues. J. Neurobiol. 20, 746-761.

 

5. Sweatt, J.D., Kennedy, T.E., Wager-Smith, K., Gawinowicz, M.A., Barzilai, A., Karl, K,A., Kandel, E.R., (1989) Development of a database of amino acid sequences for proteins identified on two-dimensional polyacrylamide gels. Electrophoresis 10, 152-157.

 

6. Barzilai, A., Kennedy, T.E., Sweatt, J.D., Kandel, E.R., (1989) 5-HT modulates protein synthesis and the expression of specific proteins during long-term facilitation in Aplysia sensory neurons. Neuron 2, 1577-1586.

 

7. Strittmatter, S.M., Valenzuela, D., Kennedy, T.E., Nerr, E.J., Fishman, M.C. (1990) Go as a major growth cone protein subject to regulation by GAP-43, Nature 344, 836-841.

 

8. Miller, B.S., Kennedy, T.E., and Streips, U.N. (1991) Molecular characterization of specific heat shock proteins in Bacillus subtilis.  Cur. Microbiol. 22, 231-236.

 

9. Kuhl, D., Kennedy, T.E., Barzilai, A., Kandel, E.R. (1992)  Long-term sensitization training in Aplysia leads to an increase in the expression of BiP, the major protein chaperon of the endoplasmic reticulum.  J. Cell Biol.119,1069-1076.

 

10. Kennedy, T.E., Kuhl, D., Barzilai, A., Sweatt, J.D., Kandel, E.R. (1992)  Long-term sensitization training in Aplysia leads to an increase in Calreticulin, a major presynaptic calcium-binding protein.  Neuron 9, 1013-1024.

 

11. Serafini, T., Kennedy, T.E., Galko, M., J., Mirzyan, C.M., Jessell, T.J., Tessier-Lavigne, M. (1994)  The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6.  Cell 78, 409-424.

 

12. Kennedy, T.E., Serafini, T., de la Torre, J., Tessier-Lavigne, M. (1994)  Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord.  Cell 78, 425-435.

 

13. Kennedy, T.E. and Tessier-Lavigne, M. (1995) Guidance and induction of branch formation in developing axons by target-derived diffusible factors.  Curr. Opin. Neurobiol. 5, 83-90.

 

14. Mitchell, K.J., Doyle, J.L., Serafini, T., Kennedy, T.E., Tessier-Lavigne, M., Goodman, C.S., Dickson, B.J. (1996).  Genetic analysis of Netrin genes in Drosophila:  Netrins guide CNS commissural axons and peripheral motor axons.  Neuron 17, 203-215.

 

15. Deiner, M.S., Kennedy, T.E., Fazeli, A., Serafini, T., Skarnes, W.C., Tessier-Lavigne, M., Sretevan, D.W. (1997).  Netrin-1 and DCC mediate axon guidance at the optic disc:  loss of function leads to optic nerve hypoplasia.  Neuron 19, 575-589.

 

16. Metin, C., Deleglise, D., Serafini, T., Kennedy, T.E., Tessier-Lavigne, M. (1997).  A role for netrin-1 in the guidance of cortical efferents.  Development. 124, 5063-5074.

 

17. Elchebly, M., Wagner, J., Kennedy T.E., Lanctor, C., Michaliszyn, E., Itie, A., Drouin, J., Tremblay, M.L. (1999).  Neuroendocrine dysplasia in mice lacking protein tryosine phosphatase sigma.  Nature Genetics 21, 330-333.

 

18. Roux PP.*, Colicos MA.*, Barker PA., Kennedy TE (1999) p75 neurotrophin receptor expression is induced in apoptotic neurons following seizure. J. Neurosci., 19 (16) 6887-6896.

 

19. Hamam, B.N., Kennedy, T.E., Alonso, A., Amaral, D.G. (2000) Morphological and Electrophysiological Characteristics of Layer V Neurons of the Rat Entorhinal Cortex, J. Comp. Neurol. 418, 457-472.

 

20. Braisted, J.E., Catalano, S.M., Stimac, R., Kennedy, T.E., Tessier-Lavigne, M., Shatz, C.J., O'Leary, D.D.M. (2000) Netrin-1 promotes thalamic axon growth and is required for the proper development of the thalamocortical projection. Journal of Neurosci. 20, 5792-5801.

 

21. Kennedy TE (2000) Cellular mechanisms of netrin function: long-range and short-range actions. Biochem. and Cell Biol. 78: 569-575.

 

22. Ellezam B, Selles-Navarro I, Manitt C*, Kennedy TE, McKerracher L. (2001) Expression of netrin-1 and its receptors DCC and UNC-5H2 after axotomy and during regeneration of adult rat retinal ganglion cells. Exp. Neurol. 168: 105-115.

 

23. Manitt, C.*, Colicos, M.*, Thompson, K.M.*, Rousselle, E.*, Peterson, A., Kennedy, T.E.  (2001) Widespread expression of netrin-1 by neurons and oligodendrocytes in the adult mammalian spinal cord. Journal of Neuroscience, 21(11):3911-3922.

 

24. Roux, P.P.*, Bhakar, A.L., Kennedy, T.E., Barker, P.A. (2001) The p75 neurotrophin receptor (p75NTR) activates Akt (PKB) through a PI3-kinase dependent pathway. J. Biol. Chem. 276:23097-23104.

 

25. Shekarabi M* and Kennedy TE. (2002) The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating cdc42 and rac1. Molecular and Cellular Neuroscience 19: 1-17.

 

26. Manitt, C.* and Kennedy, T.E. (2002) Where the rubber meets the road: Netrin expression and function in developing and adult nervous systems. Progress in Brain Research Vol 137.

 

27. Taniguchi H, Tamada A, Kennedy TE and Murakami F (2002) Crossing the Ventral Midline Causes Neurons to Change their Response to Floor Plate and Alar Plate Attractive Cues during Transmedian Migration. Dev. Biol. 249, 321-332.

 

28. Li X, Meriane M, Triki I, Shekarabi M*, Kennedy TE, Larose L, Lamarche-Vane N. (2002) The adaptor protein Nck-1 couples the netrin-1 receptor DCC (deleted in colorectal cancer) to the activation of the small GTPase Rac1 through an atypical mechanism. J Biol. Chem. 277 (40): 37788-97.

 

29. Hamam BN and Kennedy TE. (2003) Visualization of the Dendritic Arbor of Neurons in Intact 500 μm Thick Brain Slices. J Neuroscience Methods, 123, 61-67.

 

30. Luk KC, Kennedy TE, Sadikot AF. (2003) Glutamate promotes proliferation of striatal neuronal progenitors by an NMDA receptor-mediated mechanism. Journal of Neuroscience, 23: 2239-2250.

 

31. Jarjour AA*, Manitt C*, Moore SW*, Thompson KM*, Yuh S-J*, Kennedy TE. (2003) Netrin-1 is a chemorepellent for oligodendrocyte precursor cells in the embryonic spinal cord. Journal of Neuroscience, 23: 3735-3744.

 

32. Thompson KM*, Uetani N, Manitt C*, Elchebly M, Tremblay ML, Kennedy TE. (2003) Receptor protein tyrosine phosphatase sigma inhibits axonal regeneration and the rate of axon extension. Molecular and Cellular Neuroscience, 23: 681-692. featured on cover.

 

33. Jarjour AA* and Kennedy TE (2004) Oligodendrocyte Precursors on the Move: Mechanisms Directing Migration. The Neuroscientist, 10: 99-105.

 

34. Bouchard JF*, Moore SW*, Roux PP*, Shekarabi M*, Barker PA, Kennedy TE. (2004) Protein Kinase A Activation Promotes Plasma Membrane Insertion of DCC from an Intracellular Pool: A Novel Mechanism Regulating Commissural Axon Outgrowth. Journal of Neuroscience. 24: 3040-3050. Citation by Faculty of 1000 Biology.

 

35. Ruffini F, Kennedy TE, Antel JP (2004) Inflammation and remyelination in the central nervous system: a tale of two systems. Am J Pathol. 164:1519-1522.

 

36. Manitt M*, Thompson KM*, Kennedy TE. (2004) A developmental shift in expression of netrin receptors in the rat spinal cord: Predominance of UNC-5 homologues in adulthood. J Neurosci Res. 77: 690-700.

 

37. Flores C*, Manitt C*, Rodaros D, Thompson KM*, Rajabi H, Luk KC, Tritsch NX*, Sadikot A, Stewart J, Kennedy TE (2005). Netrin receptor deficient mice exhibit functional reorganization of dopaminergic systems and do not sensitize to amphetamine. Molecular Psychiatry 10: 606-612.

 

38. Sapieha PS, Duplan L, Uetani N, Joly S, Tremblay ML, Kennedy TE and Di Polo A (2005). Receptor protein tyrosine phosphatase sigma inhibits axon regrowth in the adult injured CNS. Molecular and Cellular Neuroscience. 28: 625-635.

 

39. Shekarabi M*, Moore SW*, Tritsch NX*, Morris SJ*, Bouchard JF*, Kennedy TE (2005). DCC binding netrin-1 mediates cell-substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansion. Journal of Neuroscience. 25: 3132-3141.

 

40. Petit A, Kennedy TE, Bagnard D, Doucet G. (2005). Membrane-associated guidance cues direct the innervation of forebrain and midbrain by dorsal raphe-derived serotonergic axons. Eur J Neurosci. 22:552-568.

 

41. Dillon AK, Fujita SC, Matise MP, Jarjour AA*, Kennedy TE, Kollmus H, Arnold H-H, Weiner JA, Sanes JR, Kaprielian Z. (2005) Molecular Control of Spinal Accessory Motoneuron/Axon Development in the Mouse Spinal Cord. Journal of Neuroscience, 25:10119-10130.

 

42. Moore SW*, Kennedy TE (2006) Protein Kinase A Regulates the Sensitivity of Spinal Commissural Axon Turning to Netrin-1, but does not Switch between Chemoattraction and Chemorepulsion. Journal of Neuroscience, 26: 2419-2423. 27 citations. Cited as a Must Read paper by Faculty of 1000.

 

43. Uetani N, Chagnon MJ, Kennedy TE, Iwakura Y, Tremblay ML (2006) Mammalian motoneuron axon targeting requires receptor protein tyrosine phosphatases σ and δ. Journal of Neuroscience, 26 :5872-5880.

 

44. Baker KA*, Moore SW*, Jarjour AA*, and Kennedy TE (2006) When a diffusible axon guidance cue stops diffusing: Roles for netrins regulating adhesion and morphogenesis. Current Opinion in Neurobiology 16(5):529-534.

 

45. Kennedy TE, Wang H, Marshall W, Tessier-Lavigne M. (2006) Axon Guidance by Diffusible Chemoattractants: A Gradient of Netrin Protein in the Developing Spinal Cord. Journal of Neuroscience, 34: 8866-8874. featured on cover.

 

46. Manitt C*, Wang D, Kennedy TE, Howland DR (2006) Positioned to Inhibit: Netrin-1 and Netrin Receptor Expression Following Spinal Cord Injury. Journal of Neuroscience Research, 84: 1808-1820.

 

47. Miron VE*, Rajasekharan S*, Jarjour AA*, Zamvil SS, Kennedy TE, Antel JP (2007) Simvastatin Regulates Oligodendrocyte Process Dynamics and Survival. Glia, 55: 130-143.

 

48. Howell DM, Morgan WJ, Jarjour AA*, Spirou GA, Berrebi AS, Kennedy TE, Mathers PH (2007) Molecular guidance cues necessary for axon pathfinding from the ventral cochlear nucleus. J Comp Neuro, 504: 533-549.

 

49. Jung CG, HJ Kim, Miron VE*, Cook S, Kennedy TE, Foster CA, Antel JP, Soliven B (2007). Functional consequences of S1P receptor modulation in rat oligodendroglial lineage cells. Glia, 55(16):1656-1667.

 

50. Petit A, Sellers DL, Liebl DJ, Tessier-Lavigne M, Kennedy TE, Horner PJ (2007). Adult spinal cord progenitor cells are repelled by netrin-1 in the embryonic and injured adult spinal cord. P.N.A.S. 104(45):17837-17842.

 

51. Moore SW*, Marc Tessier-Lavigne, Kennedy TE (2007) Netrins and their receptors. Adv Exp Med Biol. 621:17-31.

 

52. Costantino S*, McQuinn CG, Kennedy TE, Wiseman PW (2008). Fabrication of protein gradients for cell culture using a miniature squeegee. Journal of Biochemical and Biophysical Methods, 70(6):1192-5.

 

53. Miron VE*, Jung CG, Kim HJ, Kennedy TE, Soliven B, Antel JP (2008). FTY720 modulates human oligodendrocyte progenitor process extension and survival. Annals of Neurology, 63(1):61-71.

 

54. Darlington PJ*, Goldman JS*, Cui Q, Antel JP, Kennedy TE (2008). Widespread Immunoreactivity for NeuN (Neuronal Nuclei) in Cultured Human and Rodent Astrocytes. Journal of Neurochemistry. 104:1201-9.  

 

55. Costantino S*, Kent CB, Godin AG, Kennedy TE, Wiseman PW, Fournier AE (2008) Semi-automated quantification of filopodial dynamics. Journal of Neuroscience Methods, 171(1):165-73.

 

56. Moore SW*, Lai Wing Sun K*, Xie F, Barker PA, Conti M, Kennedy TE (2008) Soluble Adenylate Cyclase is not Required for Axon Guidance to Netrin-1. Journal of Neuroscience, 28(15):3920-4.

 

57. Darlington PJ*, Podjaski C*, Horn KE*, Costantino S*, Blain M, Saikali P, Chen Z, Baker KA*, Newcombe J, Freedman M, Wiseman PW, Bar-Or A, Kennedy TE, Antel JP (2008) Innate Immune-mediated Neuronal Injury Consequent to Loss of Astrocytes. Journal of Neuropathology and Experimental Neurology, 67(6): 590-599.

 

58. Moore SW*, Correia J*, Lai Wing Sun K*, Pool M, Fournier AE, and Kennedy TE. (2008) Rho Inhibition Recruits DCC to the Neuronal Plasma Membrane and Enhances Axon Chemoattraction to Netrin-1, Development, 135(17):2855-64.

 

59. Miron VE*, Hall JA, Kennedy TE, Soliven B, Antel JP. (2008) Cyclical and dose-dependent responses of adult human mature oligodendrocytes to fingolimod. American Journal of Pathology, 173(4):1143-52.

 

60. Bouchard JF*, Horn KE*, Stroh T, Kennedy TE (2008) Depolarization Recruits DCC to the Plasma Membrane of Embryonic Cortical Neurons and Enhances Axon Extension in Response to Netrin-1. Journal of Neurochemistry. 107: 398-417.

 

61. Jarjour AA*, Bull SJ*, Almasieh M, Rajasekharan S*, Baker KA*, Mui J, Antel JP, Di Polo A, Kennedy TE (2008) Maintenance of Axo-Oligodendroglial Paranodal Junctions Requires DCC and Netrin-1. Journal of Neuroscience. 28: 11003-11014.

 

62. Shatzmiller RA*, Goldman JS*, Simard-Émond L*, Rymar V, Manitt C*, Sadikot AF, Kennedy TE (2008) Graded Expression of Netrin-1 by Specific Neuronal Subtypes in the Adult Mammalian Striatum. Neuroscience. 157(3):621-36.

 

63. Bélisle JM, Correia JP*, Wiseman PW, Kennedy TE, Santiago Costantino (2008) Patterning protein concentration using laser-assisted adsorption by photobleaching, LAPAP. Lab on a Chip. 8(12): 2164-2167.

 

64. Rajasekharan S*, Baker KA*, Horn KE*, Jarjour AA*, Antel JP, Kennedy TE (2009) Netrin-1 and DCC Regulate Oligodendrocyte Process Branching and Membrane Extension via Fyn and RhoA. Development, 136:415-426.

 

65. Miron VE*, Zehntner SP, Kuhlmann T, Ludwins SK, Owens T, Kennedy TE, Bedell BJ, Antel JP (2009) Statin Therapy Inhibits Remyelination in the Central Nervous System. American Journal of Pathology 174(5):1880-90.

 

66. Rajasekharan S*, Kennedy TE (2009) The netrin protein family. Genome Biology, 10(9):239.

 

67. Bouvier D, Tremblay, ME, Riad M, Corera AT, Gingras D, Horn KE*, Murai KK, Kennedy TE, McPherson PS, Pasquale EB, Fon EA, Doucet G (2010) EphA4 is localized in clathrin-coated and synaptic vesicles in adult mouse brain. Journal of Neurochemistry. 113(1): 153-65.

 

68. Miron VE*, Ludwin SK, Darlington PJ*, Jarjour AA*, Soliven BS, Kennedy TE, Antel JP. (2010) Fingolimod (FTY720) Enhances Remyelination Following Demyelination of Organotypic Cerebellar Slices. Amer. J. Pathology. 176(6): 2682-94.

 

69. Rajasekharan S*, Bin JM*, Antel JP, Kennedy TE (2010) A Central Role for RhoA during Oligodendroglial Maturation in the Switch from Netrin-1 Mediated Chemorepulsion to Process Elaboration. Journal of Neurochemistry. 113(6):1589-97.

 

70. Xu B*, Goldman JS*, Rymar VV, Forget C, Lo PS*, Bull SJ*, Vereker E, Barker PA, Trudeau LE, Sadikot AF, Kennedy TE. (2010) Critical Roles for the Netrin Receptor DCC in Dopaminergic Neuronal Precursor Migration, Axon Guidance, and Axon Arborization. Neuroscience. 169(2):932-49.

 

71. Kent C, Shimada T, Ferraro G, Ritter B, Yam P, McPherson P, Charron F, Kennedy TE, and Fournier A (2010) 14-3-3 proteins regulate PKA activity to modulate growth cone turning responses. Journal of Neuroscience, 30(42):14059-67.

 

72. Andrusiak MG, McClellan KA, Dugal-Tessier D, Julian LM, Rodrigues SP*, Park DS, Kennedy TE and Slack RS (2011) Rb/E2F regulates expression of neogenin during neuronal migration. Molecular and Cellular Biology, 31(2):238-47. 12 citations

 

73. Lai Wing Sun K*, Correia JP*, Kennedy TE (2011) Netrins: versatile extracellular cues with diverse functions. Development, 138(11):2153-69.

 

74. Petit A, Sanders AD, Kennedy TE, Tetzlaff W, Glattfelder KJ, Dalley RA, Puchalski RB, Jones AR, Roskams AJ (2011) Adult Spinal Cord Radial Glia Display a Unique Progenitor Phenotype. PLoS One, 6(9):e24538.

 

75. Jarjour AA*, Durko M*, Luk TL*, Marçal N*, Shekarabi M*, Kennedy TE (2011) Autocrine netrin function inhibits glioma cell motility and promotes focal adhesion formation. PLoS One, 6(9):e25408.

 

76. Goldman JS* and Kennedy TE (2011) The clasp between NetrinG and NGL becomes crystal clear. EMBO J. 30(21):4342-4.

 

77. Cui QL, D'Abate L, Fang J, Leong SY, Ludwin S, Kennedy TE, Antel J, Almazan G (2012) Human fetal oligodendrocyte progenitor cells from different gestational stages exhibit substantially different potential to myelinate. Stem Cells and Development, 21(11):1831-7.

 

78. de Faria Jr O*, Cui QL, Bin JM*, Bull SJ*, Kennedy TE, Bar-Or A, Antel J, Colman DR, Dhaunchak A (2012) Regulation of miRNA 219 and miRNA clusters 338 and 17-92 in oligodendrocytes. Frontiers in Genetics, 3:46.

 

79. Horn KE*, Xu B*, Gobert D, Hamam BN, Thompson KM*, Wu CL, Bouchard JF*, Uetani N, Racine RJ, Tremblay ML, Ruthazer ES, Chapman CA, Kennedy TE (2012) Receptor Protein Tyrosine Phosphatase Sigma Regulates Synapse Structure, Function and Plasticity. Journal of Neurochemistry. 122(1):147-61.

 

80. Ricoult SG*, Goldman JS*, Stellwagen D, Juncker D and Kennedy TE (2012) Generation of MicroIsland Cultures using Microcontact Printing to Pattern Protein Substrates. J Neuroscience Methods. 208(1):10-17.

 

81. Sailer M, Lai Wing Sun K*, Mermut O, Kennedy TE, Barrett CJ (2012) High-throughput Cellular Screening of Engineered ECM based on Combinatorial Polyelectrolyte Multilayer Films. Biomaterials. 33(24): 5841-7.

 

82. Bin JM*, Leong SY, Bull SJ*, Antel JP, Kennedy TE (2012) Oligodendrocyte Precursor Cell Transplantation into Organotypic Cerebellar Shiverer Slices: A Model to Study Myelination and Myelin Maintenance. PLoS One, 2012;7(7):e41237.

 

83. Goulet-Hanssens A, Lai Wing Sun K*, Kennedy TE, Barrett C (2012) Photo-reversible surfaces to regulate cell adhesion. Biomacromolecules, 13(9):2958-63.

 

84. Horn KE* and Kennedy TE (2012) Putting flesh on the bones: DCC combines membrane insertion with cytoskeletal reorganization to promote chemoattraction. European Journal of Neuroscience, 36(9):3151.

 

85. Roy J, Kennedy TE, Costantino S (2013) Engineered cell culture substrates for axon guidance studies: moving beyond proof of concept. Lab on a Chip, 13(4):498-508.

 

86. Horn KE*, Glasgow SD, Gobert D, Bull SJ*, Luk T*, Girgis J*, Tremblay ME, McEachern D*, Bouchard JF*, Haber M, Hamel E, Krimpenfort P, Murai KK, Berns A, Doucet G, Chapman CA, Ruthazer ES, Kennedy TE. (2013) DCC expression by neurons regulates synaptic plasticity in the adult brain. Cell Reports, 3(1):173-85.


87. Binet F, Mawambo G, Sitaras N, Tetreault N, Lapalme E, Favret S, Cerani A, Leboeuf D, Tremblay S, Rezende F, Juan AM, Stahl A, Joyal JS, Milot E, Kaufman RJ, Guimond M, Kennedy TE, Sapieha P (2013) Neuronal ER stress impedes myeloid-cell-induced vascular regeneration through IRE1α degradation of netrin-1, Cell Metabolism, 17(3):353-371.

 

88. Wu C, Leong SY, Moore CS, Cui QL, Gris P*, Bernier LP, Johnson TA, Séguéla P, Kennedy TE, Bar-Or A, Antel JP (2013) Dual effects of daily FTY720 on human astrocytes in vitro: relevance for neuroinflammation. Journal of Neuroinflammation,10:41.

 

89. Ricoult SG*, Pla-Roca M, Safavieh R, Lopez-Ayon GM, Grütter P, Kennedy TE, Juncker D (2013) Large dynamic range digital nanodot gradients of biomolecules for cell haptotaxis made by low-cost nanocontact printing. Small, 9: 3308-3313.

 

90. Cui QL, Kuhlmann T, Miron VE, Leong SY, Fang J, Gris P*, Kennedy TE, Almazan G, Antel J (2013) Oligodendrocyte progenitor cell susceptibility to injury in multiple sclerosis. American Journal of Pathology, 183(2):516-25.

 

91. Bin JM*, Rajasekharan S*, Kuhlmann T, Hanes I*, Marcal N*, Han D*, Rodrigues SP*, Leong SY*, Newcombe J, Antel JP, Kennedy TE (2013) Full-Length and Fragmented Netrin-1 in Multiple Sclerosis Plaques are Inhibitors of Oligodendrocyte Precursor Cell Migration. American Journal of Pathology, 183(3):673-80.

 

92. Durko M*, Koty Z, Zhu L, Marçal N*, Kennedy TE, Nalbantoglu J (2013) Rat C6 glioma cell motility and glioma growth are regulated by netrin and netrin receptors unc5B and DCC. J. Cancer Therapeutics and Research, 2:18. http://dx.doi.org/10.7243/2049-7962-2-18. 

 

93. de Faria Jr O*, Moore CS, Kennedy TE, Antel JP, Bar-Or A, Dhaunchak AS (2013) MicroRNA dysregulation in multiple sclerosis. Frontiers in Genetics 22;3:311.

 

94. Goldman JS*, Ashour MA*, Magdesian MH, Tritsch NX*, Harris SN*, Gris P*, Glasgow SD*, Thompson-Steckel G*, Christofi N*, Chemali R*, Stern YE*, Grutter P*, Bouchard JF*, Ruthazer ES, Stellwagen D, and Kennedy TE (2013) Netrin-1 Promotes Excitatory Synaptogenesis Between Cortical Neurons by Initiating Synapse Assembly. Journal of Neuroscience, 33(44):17278-89.

 

95. Ricoult SG*, Thompson-Steckel G*, Correia JP*, Kennedy TE and Juncker D (2014) Tuning Cell-Surface Affinity to Direct Cell Specific Responses to Patterned Proteins. Biomaterials, 35(2):727-36. 

 

96. Thompson-Steckel G*, Kennedy TE (2014) Maintaining and Modifying Connections: Roles for Axon Guidance Cues in the Mature Nervous System. Neuropsychopharmacology Reviews,  39(1):246-247.

 

97. Leong SY, Rao VTS, Bin JM*, Gris P*, Sangaralingam M, Kennedy TE, Antel JP (2014) Heterogeneity of oligodendrocyte progenitor cells in adult human brain. Annals of Clinical and Translational Neurology, 1(4): 272-283.

 

98. Cui QL, Fang J, Kennedy TE, Almazan G, Antel JP (2014) Role of p38MAPK in S1P receptor-mediated differentiation of human oligodendrocyte progenitors. Glia, 62: 1361–1375. doi: 10.1002/glia.22688.  

 

99. Brunet I, Gordon E, Han J, Cristofaro B, Broqueres-You D, Liu C, Bouvrée K, Zhang J, Del Toro R, Mathivet T, Larrivée B, Jagu J, Pibouin-Fragner L, Pardanaud L, Machado MJ, Kennedy TE, Zhuang Z, Simons M, Levy BI, Tessier-Lavigne M, Grenz A, Eltzschig H, Eichmann A. (2014) Netrin-1 controls sympathetic arterial innervation. J. Clinical Investigation, 124(7):3230-40.

 

100. Bull SJ*, Bin JM*, Beaumont E, Boutet A, Krimpenfort P, Sadikot AF, Kennedy TE (2014) Progressive Disorganization of Paranodal Junctions and Compact Myelin Due to Loss of DCC Expression by Oligodendrocytes. Journal of Neuroscience, 34(29):9768-78.

 

101. Tepavčević, V,  Kerninon C, Stéphane Aigrot M, Meppiel E, Mozafari S, Arnould-Laurent R, Ravassard P, Kennedy TE, Nait-Oumesmar B, Lubetzki C (2014) Early netrin-1 expression impairs central nervous system remyelination. Annals of Neurology, 76(2):252-268.

 

102. Ongo G, Ricoult SG*, Kennedy TE, Juncker D (2014) Ordered, Random, Monotonic, and Non-monotonic Digital Nanodot Gradients. PLoS One, 9(9):e106541.

 

103. Ricoult SG*, Sanati Nezhad A, Knapp-Mohammady M, Kennedy TE, Juncker D (2014) Humidified Microcontact Printing of Proteins: Universal Patterning of Proteins on Both Low and High Energy Surfaces. Langmuir, 30(40):12002-10.

 

104. Beamish IV*, Kennedy TE (2015) Robo3: The Road Taken. Developmental Cell, 32(1):3-4.

 

105. Podjaski C*, Alvarez JI, Bourbonniere L, Larouche S, Terouz S, Bin J*, Lecuyer MA, Saint-Laurent O, Larochelle C, Darlington P, Arbour N, Antel JP, Kennedy TE. Prat A (2015) Netrin-1 Regulates Blood-Brain Barrier Function and Neuroinflammation. Brain 138: 1598-1612.

 

106. Ricoult SG*, Kennedy TE, Juncker D (2015) Substrate-Bound Protein Gradients to Study Haptotaxis. Frontiers in Bioengineering and Biotechnology. 3: 40. doi: 10.3389.

 

107. Godin AG, Rappaz B*, Potvin-Trottier L, Kennedy TE, De Koninck Y, Wiseman PW (2015) Spatial intensity distribution analysis reveals abnormal oligomerization of proteins in single cells. Biophysical Journal, 109, 710-721. (IF 4.0)

 

108. DeGeer J, Kaplan A, Mattar P, Morabito M, Stochaj U, Kennedy TE, Debant A, Michel C, Fournier AE, Lamarche-Vane N. (2015) Hsc70 chaperone activity underlies Trio GEF function in axon growth and guidance induced by netrin-1. Journal of Cell Biology, 210(5):817-32. 

 

109. Bin JM*, Han D*, Lai Wing Sun K*, Croteau LP, Dumontier E, Cloutier JF, Kania A, Kennedy TE. (2015) Complete loss of netrin-1 results in embryonic lethality and severe axon guidance defects without increased neural cell death. Cell Reports, 12, 1-8.

 

110. Gopal AA, Rappaz B, Rouger V, Martyn IB, Dahlberg PD, Meland RJ, Beamish IV*, Kennedy TE, Wiseman PW. (2016) Netrin-1 regulated distribution of UNC5B and DCC in live cells revealed by TICCS. Biophysical Journal, 110(3):623-34.     

 

111. Antoine-Bertrand J, Duquette PM, Alchini R, Kennedy TE, Fournier AE, Lamarche-Vane N (2016) p120RasGAP mediates netrin-1-induced cortical axon outgrowth and guidance. Journal of Biological Chemistry, 291(9):4589-602.

 

112. Mayer MC, Schauenburg L, Thompson-Steckel G*, Dunsing V, Kaden D, Voigt P, Schaefer M, Chiantia S, Kennedy TE, Multhaup G (2016). Amyloid precursor-like protein 1 (APLP1) exhibits stronger zinc-dependent neuronal adhesion than amyloid precursor protein and APLP2. Journal of Neurochemistry, 137(2):266-76.

 

113. Rone MB, Cui QL, Fang J, Wang LC, Zhang J, Khan D, Bedard M Almazan G, Ludwin SK, Jones R, Kennedy TE, Antel JP (2016) Oligodendrogliopathy in multiple sclerosis: Low glycolytic metabolic rate promotes oligodendrocyte survival. Journal of Neuroscience, 36(17):4698–4707.

 

114. Kam JWK, Dumontier E, Baim C, Brignall AC, Mendes da Silva D, Cowan M, Kennedy TE, Cloutier JF (2016) RGMb and Neogenin control cell differentiation in the developing olfactory epithelium. Development, 143(9):1534-46. doi: 10.1242/dev.118638.

 

115. Beaubien F, Raja R, Kennedy TE, Fournier A, JF Cloutier (2016) Slitrk1 is localized to excitatory synapses and promotes their development. Scientific Reports, Jun 7;6:27343. doi: 10.1038/srep27343.

 

116. Miloudi K*, Binet F, Wilson A, Cerani A, Oubaha M, Menard C, Henriques S, Mawambo G, Dejda A, Nguyen PT, Rezende FA, Bourgault S, Kennedy TE, Sapieha P (2016) Truncated Netrin-1 Contributes to Pathological Vascular Permeability in Diabetic Retinopathy. J. Clinical Investigation, 126(8):3006-22. doi: 10.1172/JCI84767.

 

117. Rao VT, Khan D, Jones RG, Nakamura DS*, Kennedy TE, Cui QL, Rone MB, Healy LM, Watson R, Ghosh S, Antel JP (2016) Potential Benefit of the Charge-Stabilized Nanostructure Saline RNS60 for Myelin Maintenance and Repair. Scientific Reports, Jul 25;6:30020. doi: 10.1038/srep30020.

 

118. Bin JM*, Harris SN*, Kennedy TE (2016). The Oligodendrocyte-Specific Antibody "CC1" Binds Quaking 7. Journal of Neurochemistry, in press PMID: 27454326

 

119. Rappaz B*, Lai Wing Sun K*, Correia JP*, Wiseman PW, Kennedy TE (2016) FLIM FRET visualization of Cdc42 activation by netrin-1 in embryonic spinal commissural neuron growth cones. PLoS One, Aug 2;11(8) :e0159405. doi: 10.1371

 

Book Chapters:

 

1. Kandel, E.R., Glansman, D., Dale, N., Barzilai, A., Kennedy, T.E., Sweatt, D (1988) A molecular biological approach to long-term memory in Aplysia. In Fundamentals of memory formation:  Neuronal Plasticity and Brain Function, H. Rahmann, ed. (Stuttgart, New York: Gustav Fisher Verlag) pp.310-323.

 

2. Glansman, D., Sweatt, J.D., Dale, N., Schacher, S., Barzilai, A., Kennedy, T.E., Kandel, E.R. (1989) Long-term memory in Aplysia:  its characterization by protein synthesis and neuronal growth. In Neuromuscular Junction, (Elsevier) pp.489-497.

 

3. Sweatt, J.D., Kennedy, T.E., Barzilai, A., Glansman, D., Kandel, E.R., (1989) Molecular mechanisms for long-term memory in Aplysia. In Brain Signal Transduction and Memory, (Academic Press) pp. 33-42.

 

4. Kennedy, T.E., Hawkins, R.D., and Kandel, E.R. (1992) Molecular interrelationships between short- and long-term memory.  In Neuropsychology of Memory 2nd edition, L.R. Squire and N. Butters eds. (Guilford Press) pp. 557-574.

 

5. Kennedy, T.E. and Kandel,. E.R. (1995) Molecular basis of memory and learning.  In Molecular biology and biotechnology:  a comprehensive desk reference, R.A. Meyers ed. (VCH Press) pp. 540-545.

 

6. Parent, J.M., Swedlow, P., Kelly, M.E., Kennedy, T.E., Tessier-Lavigne, M., Lowenstien, D.H. (1997) Mechanisms underlying network reorganization following status epilepticus. Raven Press.

 

7. Barker PA, Kennedy TE (2005) Seizure and the p75 Neurotrophin Receptor: Death by Design?  In Growth Factors and Epilepsy. Binder DK and Scharfman HE (eds). New York (Nova Science Publishers) pp. 101-110.

 

8. Kennedy TE (2005) Modulation of Axon Guidance Receptor Function During Development and Regeneration. In: What are the Possible Strategies to Regenerate Axons? Ateliers de Formation No 163. INSERM, Paris, France.

 

9. Moore SW*, Kennedy TE (2006) Axon Guidance During Development and Regeneration. Chapter 19 In: Textbook of Neural Repair and Rehabilitation. Editors: Selzer ME, Clarke S, Cohen LG, Duncan PW and Gage FH (eds). Cambridge University Press. pp.326-345.

 

10. Moore SW*, Marc Tessier-Lavigne, Kennedy TE. (2007) Chapter 2: Netrins and their receptors. In:  Axon Growth and Guidance. Editor: Dominique Bagnard. Landes Biosciences.

 

11. Moore SW*, Tessier-Lavigne TE, Kennedy TE. (2007) Netrins. Encyclopedia of Life Sciences. Editor: Irwin B Levitan. John Wiley and Sons.

 

12. Moore SW*, Tessier-Lavigne M, Kennedy TE. (2007) Pathfinding: Netrins. In: Encyclopedia of Neuroscience. 4th Edition.  Editors: George Adelman & Barry Smith. Elsevier Ltd).

 

13. Moore SW*, Kennedy TE. (2008) Dissection and Culture of Spinal Commissural Neurons Current Protocols in Neuroscience Editor: Susan Wray. John Wiley & Sons Inc.

 

14. Moore SW*, Tessier-Lavigne M, Kennedy TE. (2009) Netrins. In: Developmental Neurobiology. Editor: Larry Squire. Elsevier Ltd.

 

15. Kennedy TE (2010) Of Mice and Men, Worms and Flies, Axon Guidance and Multiple Sclerosis. MNI web site; News and Media; Neuro-science-letter.

http://www.mni.mcgill.ca/media/publications/neuroscienceletter/february10/kennedy/

 

16. Goldman JS* and Kennedy TE (2011) Neuronal Domains, In: Cellular Domains.

Editor: Ivan Robert Nabi. John Wiley & Sons Inc.

 

17. Miron VE*, Durafourt BA, Antel JP, Kennedy TE (2012) Assessment of sphingosine-1-phosphate receptor expression and associated intracellular signaling cascades in primary cells of the human central nervous system. In Sphingosine-1-Phosphate, Methods and Protocols, Methods Mol Biol: 874:141-54. Editors: Alice Pebay and Kursad Turksen. Humana Press of Springer Press, New York/Heidelberg.

 

18. Moore SW*, Kennedy TE (2014) Axon Guidance During Development and Regeneration. Chapter 19 In: Textbook of Neural Repair and Rehabilitation, 2nd edition. Editors: Selzer ME, Clarke S, Cohen LG, Kwakkel G and Miller RH (eds). Cambridge University Press. pp.301-316.

timothy.kennedy@mcgill.ca   |   3801 University Str.      Montreal, Canada